NASHVILLE, Tenn. (AP) -- Drew Brees threw two touchdown passes to Marques Colston in the fourth quarter to lead the New Orleans Saints to their fifth straight victory with a 22-17 win over the Tennessee Titans on Sunday

The NFC South-leading Saints (10-3) had little trouble picking up yards, but struggled to score until Brees and Colston connected on passes of 35 and 28 yards.

The Titans (7-6) twice had the ball in the final minutes with a chance to win. The first time, New Orleans stopped backup Jake Locker on fourth-and-1 at the Saints 24 with 2:18 left. The second time, Jo-Lonn Dunbar sacked a scrambling Locker on third-and-goal as time expired.

The Titans' loss helped clinch the AFC South for the Houston Texans.

Brees threw for 347 yards and joined Hall of Famer Johnny Unitas as the only quarterbacks to throw a touchdown pass in 40 straight games.

Locker replaced Matt Hasselbeck, who hurt his left calf after chasing a tipped pass in the second quarter.