INDIANAPOLIS (AP) -- Peyton Manning threw for three touchdowns in easily outplaying younger brother Eli as the Indianapolis Colts routed the New York Giants 38-14 Sunday night.

In the second NFL meeting of siblings as starting quarterbacks, Peyton Manning got lots of help from his running game and a Colts defense that was overrun last week against Houston. Joseph Addai rushed for 92 yards, Donald Brown added 69 and Indianapolis (1-1) forced Eli Manning to fumble twice, resulting in 14 points.

The brothers chatted in pregame warmups and twice shook hands at the coin toss. Then Peyton guided the Colts to a 24-0 halftime lead, including a 98-yard drive capped by Dallas Clark's 50-yard TD catch.

The Giants are 1-1.

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