HOUSTON (AP) -- Danieal Manning and Kareem Jackson returned interceptions for touchdowns and Matt Schaub threw two TD passes in the Houston Texans' 38-14 win over the Tennessee Titans on Sunday.

Arian Foster had a touchdown run for the Texans (4-0), who continued the best start in club history.

Titans quarterback Jake Locker left in the first quarter and did not return after hurting his left, non-throwing shoulder on a hit by Glover Quin. Locker hurt the same shoulder in the season opener against New England.

Matt Hasselbeck threw two touchdown passes in relief of Locker for the Titans (1-3). Chris Johnson carried 25 times for 141 yards, more than tripling his rushing total through the first three games.