LONDON (AP) -- Days ago Two-time men's champion Rafael Nadal was upset by 135th-ranked Steve Darcis.
A day later, a whole slew of top-seeds followed Nadal out.
Seven-time champion Roger Federer was stunned by 116th-ranked Sergiy Stakhovsky in the second round of Wimbledon on Wednesday, his earliest loss in a Grand Slam tournament in 10 years.
The 27-year-old Ukrainian outplayed Federer on Centre Court, winning 6-7 (5), 7-6 (5), 7-5, 7-6 (5) in one of the biggest upsets in Grand Slam history.
The Women's side also saw many top-seeds wither away.
Maria Sharapova was knocked out of Wimbledon by the 131st-ranked qualifier on a day when injuries forced the withdrawal of seven other players.
The third-seeded Sharapova, the Wimbledon champion in 2004, lost 6-3, 6-4 to Michelle Larcher de Brito of Portugal in the second round at the All England Club.
Seven players were knocked out of Wimbledon on Wednesday by withdrawals or mid-match retirements, believed to be the most in one day at a Grand Slam tournament in the 45-year Open era.
Second-seeded Victoria Azarenka and sixth-seeded Jo-Wilfried Tsonga were other notable players departing on Day 3 at the All England Club.
Also out: Steve Darcis, the man who stunned Rafael Nadal in the first round; John Isner, who won the longest match in tennis history at Wimbledon in 2010; 10th-seeded Marin Cilic; 2006 quarterfinalist Radek Stepanek; and Yaroslava Shvedova.
The International Tennis Federation said it believed the previous high total for one day at a major tournament was five, which happened on the first day of competition at Wimbledon last year, June 25.